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21 October, 2019 00:00 00 AM
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Editor Speaks

M. Shamsur Rahman
Editor Speaks

Osteoporosis is commonest metabolic bone disease, occurs in old age and different from osteomalacia - rickets. There is progressive decrease in the density of bones that weakens them making prone to fracture. In contrast to osteomalacia calcium phosphate per 100 gm bone is normal.

Bone contain minerals e.g. calcium and phosphorus rendering them hard and dense. The body requires an adequate supply of calcium, minerals and sufficient Parathyroid, Growth, Calcitonin, Estrogen (women), Testosterone (men) hormones with vitamin D that is needed to absorb calcium. From birth till adulthood bones are developing and strengthening. The peak bone mass occurs at the age of 20 e.g. before 40 years. With advancing age there occurs resorption and new bone cells deposition i.e. osteoid formation (remodeling).

In osteoporosis bone loss outpasses the deposition resulting diminished organic matrix rather than abnormal bone calcification. The osteoblastic activity and rate of bone deposition is less. There is negative calcium balance, the matrix of bone become thin causing pathological fracture, compression fracture of vertebra, fracture neck of femur, Colles’ fracture etc. by mild trauma. In hyperparathyroidism the cause of diminished bone is access osteoblastic activity. Usual causes of osteoporosis are: less physical stress on bone by inactivity, malnutrition with insufficient protein in matrix, lack of vitamin C which is necessary for intercellular substance of all cells including osteoblast, post menopausal with lack of oestrogen which stimulate osteoblast, old age with less anabolic functions, Cushing’s disease, Acromegaly with lack of sex hormone – access adrenocortical hormones – lack of insulin etc. After menopause, women lose approximately 30% cortical bone and 50% trabecular bone.   

 

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Editor : M. Shamsur Rahman

Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

Editor : M. Shamsur Rahman
Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

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