Friday 22 February 2019 ,
Friday 22 February 2019 ,
Latest News
  • Chawakbazar fire virtually repeats 2010 Nimtali tragedy
  • UK deeply saddened over Dhaka fire
  • BNP blames govt's irresponsibility for Chawkbazar fire
  • Shamima not a Bangladeshi citizen; no entry for her: Dhaka
  • Provide proper treatment to Chawkbazar fire victims: PM
  • probe body formed over Chawkbazar fire
  • Death toll jumps to 81 in Chawkbazar fire
10 September, 2018 00:00 00 AM

Hypertension drugs could prevent memory loss in lupus patients, study suggests

MedicalXpress
Hypertension drugs could prevent memory loss in lupus patients, study suggests
Exposure to DNRAbs (right) reduces the number of neurons and neuronal connections in the CA1 region of the hippocampus, a brain region important for spatial memory. Memory loss can be prevented in mice by ACE inhibitors such as captopril that block the activation of brain cells called microglia. Credit: Nestor et al., 2018

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.

SLE is a complex autoimmune disease that arises when the body starts to make antibodies that target its own, healthy cells, often specifically recognizing DNA. Patients can suffer a wide variety of symptoms, but as many as 90% develop neuropsychiatric lupus, which is often characterized by cognitive impairments such as memory loss or confusion.

Betty Diamond and colleagues at The Feinstein Institute for Medical Research in Manhasset, NY, previously found that lupus patients experiencing memory loss often produce antibodies—called DNRAbs—that recognize both DNA and a critical brain protein called the NMDA receptor, NMDAR. Antibodies are usually unable to enter the brain, but, after injury or infection, DNRAbs are thought to gain temporary access to the brain, where they can target neurons expressing NMDAR. This causes the neurons to die or lose the synapses that connect them to neighboring nerve cells, resulting in memory loss or other cognitive defects.

Diamond and colleagues suspected that brain cells called microglia might be responsible for trimming the connections between neurons after exposure to DNRAbs. These cells help clear away the debris of dead and dying neurons and can also remove excessive or unwanted synapses during brain development.

To address the role of microglia in SLE, Diamond and colleagues analyzed mice that produce DNRAbs capable of penetrating the brain and inducing memory loss. The researchers found that microglia are activated when DNRAbs enter the brain and that a protein called C1q attracts microglia to the synapses of neurons targeted by these antibodies. Deleting the C1q protein, or depleting the microglial cells themselves, prevented neurons from losing their synapses after exposure to DNRAbs.

ACE inhibitors such as captopril are a class of drugs used to treat high blood pressure. They are also known to block the activation of microglia. Diamond and colleagues found that captopril treatment protected neurons from DNRAbs and preserved the memory of mice producing these antibodies.

"Our study suggests that ACE inhibitors are a promising class of therapeutics that can easily move into clinical trials aimed at mitigating the cognitive dysfunction associated with neuropsychiatric lupus," Diamond says.

 

Comments

Most Viewed
Digital Edition
More story
From the Editor

From the Editor

Our cover story this week is on Dental Disorders. Teeth are a very important part of the human body. They are the body's hardest and most durable…
Cancer’s long-term prognosis: As an oncologist I’ve never been so hopeful

Cancer’s long-term prognosis: As an oncologist I’ve never been so hopeful

“You’re an oncologist, isn’t that depressing?” Answering this question, posed with equal parts dread and fascination, is an occupational…
What are the most common dental problems?

What are the most common dental problems?

Tammy Davenport    Dental problems are never any fun, but the good news is that most of them can be easily prevented. Brushing twice a day,…
Tooth, cavities and root canal

Tooth, cavities and root canal

Our dental surgeons now a days talk about re-construction of a broken tooth with a chemical compound they call 'miracle mix' or magic mix'…
What can you do about sensitive teeth?

What can you do about sensitive teeth?

If you pass on hot or cold drinks because you know they’ll make your teeth hurt, it may be time to talk to your dentist about the possibility that…
Everything you need to know about bad breath

Everything you need to know about bad breath

Tim Newman Bad breath affects an estimated 25 percent of people. There are a number of possible causes of halitosis, but the vast majority come down to…
7 Daily ways to protect your teeth

7 Daily ways to protect your teeth

Some say the eyes are the window to the soul. But if you really want to know what someone’s about, check their smile. A welcoming show of pearly…
Surprise rheumatoid arthritis discovery points to new treatment for joint inflammation

Surprise rheumatoid arthritis discovery points to new treatment for joint inflammation

Researchers at the University of Virginia School of Medicine have identified an unexpected contributor to rheumatoid arthritis that may help explain the…
Enhance social emotional learning along with cognitive capacity of the children with NDDs

Enhance social emotional learning along with cognitive capacity of the children with NDDs

Neurodevelopmental disorders (NDDs) are indicated by developmental deficits which usually appear at the early age of a child’s development and can…
icddr,b explores sustainable ways to improve WASH and menstrual hygiene management in RMG factories

icddr,b explores sustainable ways to improve WASH and menstrual hygiene management in RMG factories

icddr,b in partnership with The Waterloo Foundation, UK have undertaken a new study to explore water, sanitation and hygiene (collectively known as WASH)…
Researchers find clues that depression may speed brain aging

Researchers find clues that depression may speed brain aging

Memory and thinking skills naturally slow with age but now scientists are peeking inside living brains to tell if depression might worsen that decline—and…
FDA approves Spravato (esketamine) nasal spray for adults with treatment-resistant depression

FDA approves Spravato (esketamine) nasal spray for adults with treatment-resistant depression

The Janssen Pharmaceutical Companies of Johnson & Johnson recently announced that the U.S. Food and Drug Administration (FDA) Psychopharmacologic…
FDA approves Wixela Inhub (fluticasone propionate and salmeterol inhalation powder, USP), first generic of advair diskus

FDA approves Wixela Inhub (fluticasone propionate and salmeterol inhalation powder, USP), first generic of advair diskus

Mylan N.V. recently announced the U.S. Food and Drug Administration (FDA) approval of Wixela Inhub (fluticasone propionate and salmeterol inhalation powder,…

Copyright © All right reserved.

Editor : M. Shamsur Rahman

Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

Editor : M. Shamsur Rahman
Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

Disclaimer & Privacy Policy
....................................................
About Us
....................................................
Contact Us
....................................................
Advertisement
....................................................
Subscription

Powered by : Frog Hosting