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2 December, 2017 00:00 00 AM
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New migraine drugs show promise

New migraine drugs 
show promise

Two new migraine drugs have shown promise in late-stage clinical trials. The drugs were designed specifically to target a pathway believed to be important in these headaches. In stage 3 clinical trials, the drugs were found to work exceptionally well for some people, but not as well for others. Still, headache experts are enthused about the new research. "It's exciting to have a new choice in prevention of migraine, especially for those without a complete response to current effective treatments," said Dr. Andrew Hershey. He's director of neurology and director of the Headache Center at Cincinnati Children's Hospital Medical Center.

"About 20 to 25 percent of those studied had a huge response," Hershey said. "If we can keep whittling away at 15 percent or 20 percent of patients at a time, soon we'll get to 100 percent of those treated for migraine becoming headache-free or near headache-free."

Migraine is a severe headache, lasting hours or longer. Migraines often are accompanied by other symptoms, such as sensitivity to light or sound, and nausea.

The two new drugs are monoclonal antibodies. They attach to other proteins to disrupt how those proteins act. Both of the drugs act on a substance called calcitonin gene-related peptide (CGRP), according to Hershey.

It's not exactly clear how the drugs help disrupt migraines, but CGRP is known to be involved with the way nerves control pain and with blood vessel activity. Both nerves and blood vessels are involved in migraines.

One of the stage 3 trials looked at how the monoclonal antibody erenumab treated episodic migraines. The study, led by Dr. Peter Goadsby of King's College London, in England, defined those migraines as ones that occur from four to 15 days a month.

Participants included nearly 1,000 people with episodic migraines, representing 121 sites across North America, Europe and Turkey. They were randomly assigned into one of three groups. One group received 70 milligrams (mg) of the drug by injection once a month. Another group received 140 mg of the drug by injection monthly. The third group received a placebo.

More than 43 percent of those on the lowest dose of the drug and 50 percent of those on the highest dose cut their average number of migraines a month by at least half. Less than 27 percent of those given the placebo had a similar response.

The average number of migraine days dropped by 1.8 days for people taking the placebo. People on the lowest dose of the drug had 3.2 fewer days with a headache, and those on the higher dose had 3.7 fewer days with a migraine.

The second stage 3 trial, led by Dr. Stephen Silberstein from the Jefferson Headache Center in Philadelphia, included more than 1,100 people from 132 sites in nine countries. All participants had chronic migraines. That means they had headaches 15 or more days a month, and migraines at least eight days a month.

The study volunteers were randomly placed into one of three groups. One group got an injection of the monoclonal antibody fremanezumab at a dose of 675 mg the first month and then a placebo at weeks 4 and 8.

The second group received monthly fremanezumab with a starting dose of 675 mg and then 225 mg for the second and third month. The third group received a placebo for all three months.

Among those who got only the initial injection, 38 percent reduced their average number of headaches by at least half.

By comparison, 41 percent of those who got a monthly injection also cut their headache days by at least half, as did 18 percent of those in the placebo group.

HealthDay

 

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Editor : M. Shamsur Rahman

Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

Editor : M. Shamsur Rahman
Published by the Editor on behalf of Independent Publications Limited at Media Printers, 446/H, Tejgaon I/A, Dhaka-1215.
Editorial, News & Commercial Offices : Beximco Media Complex, 149-150 Tejgaon I/A, Dhaka-1208, Bangladesh. GPO Box No. 934, Dhaka-1000.

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